At present it is confirmed that high level of Vitamin D protects from: age-related macular degeneration, depression, infertility, cutaneous diseases.

Yes, of course! Better than cyclical variations, is a permanent level of 25-OH D the interval 60-80 ng/ml!

Yes, I agree, but I am interested if it is the absence of seasonal variation in Vitamin D levels or the normalisation of Vitamin D levels that is beneficial. It is difficult to prove causalities.

Hi, these are data dealing with the influence of vit.D levels and malgnancies  - on the formation of tumour, efficacy of supplementation and  influence on the course of cancer.I added some references.

Lack of vitamin D levels influence on the formation of tumors

The higher incidence of CRC, especially at levels below 50 nmol / l

For other types of cancer inconclusive results. * **

On the contrary, confirmed the higher incidence of pancreatic cancer  high-level 25- (OH) D supplementation and vitamin D levels ( 9 meta-analysis) ***

* Ma Y, Zhang P, Wang F et al.Association Between Vitamin D and risk of colorectal cancer: a systematic review of prospective studies.J Clin Oncol 2011; 29 (28): 3775-3782

** Zgaga L, Agakov F, E et Theodoratou al.Model selection approach suggests causal association Between 25-hydroxyvitamin D and colorectal one cancer.PLoS 2013; 8 (5): e63475

*** Liu SL Zhao YP Dai MH et al.Vitamin D status and the risk of pancretaic cancer: a meta-analysis.Chin Med J 2013; 126 (17): 3356-3359

Supplementation with vitamin D

In relatively low doses daily needs not reduced the incidence of tumors,primary or secondary prevention is not  recommended *

Probably not apply influence vitamin D levels in tumor initiation, but significantly interferes with the stage of tumor growth **

* Bouillon R, Van Schoor NM, Gielen E et al. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab 2013;98(8):E1283-E1304

** Giovannucci E.The epidemiology of vitamin D and cancer risk.In:Trump DL, Johnson CS (eds).Vitamin Dabd cancer.Springer Sience + Business Media LLC 2011:73-96

Lack of vitamin D levels influence on the course of cancer

Shorter OS for pts. input low level of 25- (OH) D of 46 nmol / l - tumors of the breast, colon, lung and malig.lymfomem *. Differences in survival between extreme quartiles significant levels of vitamin D levels in lung cancer (5.3 m in the lowest quartile vs. 22.6 m on the top)

Lower mortality in early NSCLC with the level of vitamin D levels over 40nmol / la revenue over 370IU vitamin D levels **

+ EBC deficit vitamin D levels: a higher risk of distnce metastases(RR 1.7) ***

A meta-analysis of 5 studies pts. with breat cancer- higher mortality of pts. in the owest quartile levels of vitamin D levels (p

Vitamin D intake is important, and in humans the "working part" needs to be activated to take part in metabolism.

Good intestinal absorption ( food rich in vitamin D ), walking and sun can do, in prevention of diseases and ageing. Oral administration of   provitamin D supplement is very good.

Some endocrinology, reumathology and cutaneous diseases are whole body disorders with insufficient vitamin, as it is specific hereditary pattern. In parathyroid primary hyperpatathyroidism vitamin D is antagonist of parathormone in calcium metabolism. So it is not always about intestinal absorption.We are dealing with whole body endocrine metabolic dance.

In malignancies, considering metabolic theory of oncogenesis, the role of vitamin D and other liposolubile vitamins is under question.The anaerobic metabolism in viable malignancies is triggered by low oxygen levels, and that increases the level of free radicals. Lack of oxygen in cell, the respiration is impaired. First on local level and than on whole body level.

For this answer an experts of biochemical pathophysiology are important. And we need a bond between fundamental cell investigations and clinical solutions. I haven't find this answer yet!

Best regards  and good luck!

Vitamin D has an important role in regulating immunological response in inflammatory diseases. Vit D deficiency can cause suseptibility to periodontitis.

Article Association between serum levels of vitamin D and chronic pe...

As is always the case with this unscientific news, it scares people and makes them act on their own. Thus the demand and consumption of Vitamin D is growing (The pharmaceutical industries!).

Which is worse with hypovitaminosis or hypervitaminosis?

Dr. Felipe Hernández Luis