BDNF and NGF plays important roles in the regulation of central nervous system and many articles have been published about them. However, I did not find their half-life in the human blood.
Dear Hamed,
Circulating BDNF has been shown to have a half-life of less than 10 min
Pharm Res. 1997 Aug;14(8):1085-91.
Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity.
Sakane T, Pardridge WM.
Exp Neurol. 1994 Jun;127(2):178-83.
Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats.
Tria MA, Fusco M, Vantini G, Mariot R.
...murine NGF has a distribution half-life of about 5.4 min and an elimination half-life of 2.3 h following intravenous injection. When administered by subcutaneous (sc) injection, the elimination half-life is prolonged to 4.5 h. Administration of NGF by sc continuous infusion, using mini-osmotic pumps, provides stable, dose-related levels of circulating NGF within few days from pump implantation. Upon removal of the pump, NGF levels show a rapid decay (t1/2 about 1.5 h) followed by a slow elimination phase (t1/2 about 150 h). These pharmacokinetic parameters might serve for selection of an appropriate administration route and dose regimen that would optimize schedule-dependent expression of NGF therapeutic activity.
Dear Beatrice
Thank you for your valuable information.
Are these information valid for humans?
Dear Hamed,
I suggest that you contact Dr WM Pardridge on the following address:
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