How do we calculate the loading dose and maintenance dose in development of SR multiple unit pellets (Coated) ?

In some disease conditions the there is lag time to achieve the PDC in the therapeutic range. Therefore, there is need to administered loading dose separately or together with maintenance dose.

02 March 2019 1,104 1 View

Pelletization and pellet coating is/being explored to satisfy the need of Loading dose and maintenance dose concept ?

Loading dose and maintenance dose concept

11 December 2018 7,861 0 View

What are the challenges for developing protein and peptide drug delivery?

Protein & Peptide Drug Delivery

10 November 2018 5,349 3 View

Is intra muscular parenterals are suitable for large mol. Weight drugs about 850 Dalten ?

Intra muscular or depot preparation s

10 November 2018 3,821 0 View

Are the carbon tubes a better approach for cancer drug targeting ?

In relation to active drug targeting

06 July 2018 10,020 0 View

What is maximum amount of residual solvent allowed in oral and /or parenteral formulation

05 June 2017 2,616 0 View

Computer Aided Drug Delivery

Reference book or Journal etc

01 January 1970 7,961 3 View

In vitro modelling for renal cell cancer

Cell toxicity study

01 January 1970 8,835 1 View

Could you suggest the method of preparation of nanoparticles free from organic solvent and easy to scale up ?

Drug loaded nanoparticles especially polymeric

01 January 1970 1,150 4 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

How to formulate Energy minimization in Molecular dynamics simulation for alloys using meam potential?

during MD simulation, the atoms are not moving as per required. The problem (as per my observation) lies in energy minimization technique. upon application of tensile strain in x or y direction,...

22 February 2021 380 5 View

Does anyone have any ideas why drug-resistant malaria is increasing in Southeast Asia even when those drugs are no longer used?

When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...

21 February 2021 6,084 5 View

What is the most prevalent drug related problem in the developed countries?

Detecting the drug related problems is an important step in the pharmaceutical care plan

21 February 2021 5,421 3 View

No title

19 February 2021 8,647 3 View

How to improve dissolution of neosome?

I have made neosome from herbal drug. Neosomes are stable. But I face problems in dissolution. I used minimum ratio of 1:1:0.25 ( Drug:span 60: Cholesterol and GMs. Now how can I active better...

17 February 2021 3,584 1 View

How to determine the drug loading and the drug release capacity of a polymer micelle using UV spectroscopy?

Currently, I am working on PLA-PEG copolymer micelle for the drug delivery system. I have seen several papers where some researcher talks to centrifuge the drug-loaded micelle to separate the...

13 February 2021 5,822 7 View

Formulate model for one integer optimization?

I am working on one optimization problem. the model with two states, the transition between the two states based on one threshold value (L = 5, which L< 5 -> Normal state, L== 5 ->...

11 February 2021 4,045 3 View