How do we calculate the loading dose and maintenance dose in development of SR multiple unit pellets (Coated) ?

In some disease conditions the there is lag time to achieve the PDC in the therapeutic range. Therefore, there is need to administered loading dose separately or together with maintenance dose.

02 March 2019 1,104 1 View

What is the fate of large Mol. Wt. drugs that are administered in parenterals ?

Development of parenteral formulation of large Mol. Wt. (More than 800 Dalten substance.

10 November 2018 9,092 1 View

What are the challenges for developing protein and peptide drug delivery?

Protein & Peptide Drug Delivery

10 November 2018 5,349 3 View

Is intra muscular parenterals are suitable for large mol. Weight drugs about 850 Dalten ?

Intra muscular or depot preparation s

10 November 2018 3,821 0 View

Are the carbon tubes a better approach for cancer drug targeting ?

In relation to active drug targeting

06 July 2018 10,020 0 View

What is maximum amount of residual solvent allowed in oral and /or parenteral formulation

05 June 2017 2,616 0 View

Computer Aided Drug Delivery

Reference book or Journal etc

01 January 1970 7,961 3 View

In vitro modelling for renal cell cancer

Cell toxicity study

01 January 1970 8,835 1 View

Could you suggest the method of preparation of nanoparticles free from organic solvent and easy to scale up ?

Drug loaded nanoparticles especially polymeric

01 January 1970 1,150 4 View

Adherance of Polyaniline coating over stainless steel?

Is the electropolymerisation of polyaniline coating over stainless steel (SS) via Cyclic voltammetry technique is really adherant? Else how to improve the adhesion of the coating, whether any...

01 March 2021 8,220 2 View

Is there a method of determining feed digestibility without the need to re-pellet the feed?

I am aiming to determine the ADC values of a commercial fish feed, but I do not have a steam pelleter or extruder available to me. Ideally, the pellets could be coated with some inert marker....

28 February 2021 7,967 3 View

How to immerse bricks in wax ( for coating ) ?

Do we immerse the bricks horizontally or vertically ? #bricks#waterproofingsurface#civil#engeenering#chemicalengineering#wax#parafinwax

28 February 2021 6,685 2 View

For gelatin coating for culturing HUVEC.Should the gelatin be made in sterile water or PBS? Do I need to autoclave the gelatin soln after making it ?

I want to use 0.1% gelatin. Should that be made in PBS or sterile water? Should I autoclave the gelatin soln after making it in water/PBS?

28 February 2021 274 2 View

Why is my platinum counter electrode getting dirty during electrodeposition?

I am conducting anodic electrodeposition of MnO2 onto a stainless steel substrate, using a platinum strip as a counter electrode. This is done galvanostatically, with the current held between 5...

27 February 2021 1,829 3 View

What pH condition required to coat APTES on silica coated Fe3O4?

It's a hydrolysis reaction, which may produce by either acid or base-catalyzed reaction. so can anybody help me with this, which condition is suitable for this reaction?

26 February 2021 1,760 8 View

What is the best surface to culture cells isolated from a skin biopsy?

Hello, recently I am having some difficulties with maintaining the cell culture of primary cells isolated from a skin biopsy (normal and malignant). The coating of culture plates with Matrigel (a...

26 February 2021 6,151 2 View

Unknown debris sheets observed in cell culture flasks?

Hi, We culture neural progenitor cells in T175 culture flasks coated with PLO-Laminin. We have successfully grown these cells with our protocol for months. Recently, we observed large sheets...

25 February 2021 3,443 4 View

How does charge on working electrode changes with rising potential?

During performing CV of a GCE or modified GCE, we rise the potential in the first half of the cycle and reduce it in reverse half. During the first half, what is the nature of charge on GCE or...

25 February 2021 7,994 3 View

Experimental Design: How deal with pseudreplicates with immunological and clinical-chemical paramaeters?

Hello everybody, I am investigating the influence of a toxinon various clinical-chemical and haematological parameters in fish. I have three treatments (control, low dose, high dose) in my...

24 February 2021 1,243 1 View