Could you suggest the method of preparation of nanoparticles free from organic solvent and easy to scale up ?

More Pradum Pundlikrao Ige's questions See All

How do we calculate the loading dose and maintenance dose in development of SR multiple unit pellets (Coated) ?

In some disease conditions the there is lag time to achieve the PDC in the therapeutic range. Therefore, there is need to administered loading dose separately or together with maintenance dose.

02 March 2019 1,216 1 View

Pelletization and pellet coating is/being explored to satisfy the need of Loading dose and maintenance dose concept ?

Loading dose and maintenance dose concept

11 December 2018 7,978 0 View

Is intra muscular parenterals are suitable for large mol. Weight drugs about 850 Dalten ?

Intra muscular or depot preparation s

10 November 2018 3,926 0 View

What is the fate of large Mol. Wt. drugs that are administered in parenterals ?

Development of parenteral formulation of large Mol. Wt. (More than 800 Dalten substance.

10 November 2018 9,206 1 View

What are the challenges for developing protein and peptide drug delivery?

Protein & Peptide Drug Delivery

10 November 2018 5,477 3 View

Are the carbon tubes a better approach for cancer drug targeting ?

In relation to active drug targeting

06 July 2018 10,130 0 View

What is maximum amount of residual solvent allowed in oral and /or parenteral formulation

Toxicity

05 June 2017 2,733 0 View

Computer Aided Drug Delivery

Reference book or Journal etc

01 January 1970 8,081 3 View

In vitro modelling for renal cell cancer

Cell toxicity study

01 January 1970 8,971 1 View

• What the possible Persistent Organic Pollutants and Heavy metals present in fluorspar, sediments, and water bodies around its mining area?

Approximate concentrations are require in compared with the WHO permissible limts

11 August 2024 2,723 1 View

Adhesion strength of coating?

How can I determine a good adhesion strength range for coatings on polymer surfaces, such as DLC on polymer substrates? Is there a specific threshold for adhesion strength (from T-peel tests)...

10 August 2024 942 3 View

Basis set and input instruction to calculate HOMO and LUMO using Orca for Imidazolium based organic salts?

Hey there, As a synthetic chemist delving into theoretical calculations for my imidazolium-based organic molecules, I would greatly appreciate any guidance on the appropriate input instructions...

09 August 2024 5,444 7 View

Hello researchers Is this a random laser or just fluorescence?

I am using Rhodamine6G as gain medium and silver nanoparticles as scatterers on a microscope slide and laser input 532 nm comes from above.

09 August 2024 9,894 2 View

How to increase simulation box size?

We intend to study the interaction between peptides and polymer (like PP, PE and PS) through MD simulations using Martini force fields ( Martini 2 for PP and Martini 3 for PE, PS). We have...

08 August 2024 4,842 0 View

How to prepare the nanoparticle treated fungal sample for Environmental SEM analysis?

A fungal strain was treated with nanoparticles. We want to do an environmental SEM analysis. So could anyone share your views on preparing the sample? Thank you.

07 August 2024 5,307 1 View

What is the solvent for 8YSZ nano material?

I need to do some experiment with it in liquid form.

07 August 2024 613 3 View

Separation of organic acids-HPLC?

Hello What should be done to separate and identify organic acids in HPC when their RetTime is the same?Like oxalic acid with Propanoic Acid.or acids that have a very close RetTime.

07 August 2024 8,782 3 View

How to heat polymer for about 130° without oil bath ?

is there any other way to heat a polymer evenly other than oil bath if so what are those and how to use it

06 August 2024 947 1 View

How does one derive the standard deviation of a scale?

Dear all, I am working on analyzing data from a survey on student satisfaction. The survey contains items with a 7-point Likert response format that produce 12 scales related to different areas...

05 August 2024 2,141 4 View

Anupma Thakur

Sir,

Hydrothermal synthesis would be good option for nanoparticles synthesis.

John Clarkson

See [1]: Block co-polymers can form micelles as an organic solvent free nanoparticle delivery system.

[1] Encapsulation of Hydrophobic Drugs in Pluronic F127 Micelles: Effects of Drug Hydrophobicity, Solution Temperature, and pH

Pradum Pundlikrao Ige

I fully agreed to John Clarkson. Thank You.

Also see latest volume of Methods in Enzymology, Vol 590: NanoArmoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes, for related information.

http://www.sciencedirect.com/science/journal/00766879/590/supp/C?sdc=1