How do we calculate the loading dose and maintenance dose in development of SR multiple unit pellets (Coated) ?

In some disease conditions the there is lag time to achieve the PDC in the therapeutic range. Therefore, there is need to administered loading dose separately or together with maintenance dose.

02 March 2019 1,104 1 View

Pelletization and pellet coating is/being explored to satisfy the need of Loading dose and maintenance dose concept ?

Loading dose and maintenance dose concept

11 December 2018 7,861 0 View

What is the fate of large Mol. Wt. drugs that are administered in parenterals ?

Development of parenteral formulation of large Mol. Wt. (More than 800 Dalten substance.

10 November 2018 9,092 1 View

What are the challenges for developing protein and peptide drug delivery?

Protein & Peptide Drug Delivery

10 November 2018 5,349 3 View

Is intra muscular parenterals are suitable for large mol. Weight drugs about 850 Dalten ?

Intra muscular or depot preparation s

10 November 2018 3,821 0 View

What is maximum amount of residual solvent allowed in oral and /or parenteral formulation

05 June 2017 2,616 0 View

Computer Aided Drug Delivery

Reference book or Journal etc

01 January 1970 7,961 3 View

In vitro modelling for renal cell cancer

Cell toxicity study

01 January 1970 8,835 1 View

Could you suggest the method of preparation of nanoparticles free from organic solvent and easy to scale up ?

Drug loaded nanoparticles especially polymeric

01 January 1970 1,150 4 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

How to quantify carbon deposition on CuZnAl catalyst?

Dear All, I want to quantify carbon deposition on the surface of the CuZnAl catalyst. I have tried thermogravimetric analysis, but I've got weight gain as the active Cu- get oxidised. Does anyone...

01 March 2021 1,907 3 View

Why Trivalent chromium start precipitating above PH 5 ? Moreover discuss difference between adsorption of chromium and precipitation of chromium ?

I am a student of MS Environmental Engineering and started my research phase. I am working on metal removal ( chromium iii ) by using activated carbon prepared from the agricultural feedstock. So...

01 March 2021 5,475 2 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

How can I assign a velocity along one direction to CO2 molecules in a molecular dynamics simulation using GROMACS?

Dear all, I am trying to perform a MD simulation about the interaction between CO2 and a polymer. I create my model, solvate it and perform the NVT and NPT equilibration. Now I am not able to...

26 February 2021 10,014 3 View