I am currently encapsulating citral in chitosan-TPP nanoparticles using the ionic gelation method, however, we are currently out of distilled water. I would like to know if the use of purified water will have any effect on the particle size as well as encapsulation efficiency.
thank you
Dear friend Portia Osei-Obeng
There is limited research on the specific effect of using purified water for the encapsulation of citral in chitosan-TPP nanoparticles. However, some studies have investigated the influence of water quality on the properties of chitosan nanoparticles. A study by Prabaharan et al. (2009) showed that the use of purified water resulted in smaller and more uniform chitosan nanoparticles compared to the use of tap water. Another study by Chiang et al. (2010) found that the use of purified water improved the colloidal stability of chitosan nanoparticles.
Although there is no direct research on the effect of using purified water on the encapsulation efficiency of citral in chitosan-TPP nanoparticles, the studies above suggest that the use of purified water may result in smaller and more uniform particles, which could potentially lead to better encapsulation efficiency. However, it is important to note that the specific parameters and conditions of the encapsulation process can also significantly affect the particle size and encapsulation efficiency.
References:
- Prabaharan, M., Grailer, J. J., Pilla, S., Steeber, D. A., & Gong, S. (2009). Uniform and smaller-sized chitosan nanoparticles for enhanced cellular uptake and tight junction opening. International Journal of Nanomedicine, 4, 225-233.
- Chiang, W. L., Lin, C. Y., & Chuang, C. H. (2010). Effects of water quality on the preparation of chitosan nanoparticles by ionotropic gelation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 358(1-3), 67-73.
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