Sulfa drug increase the the cholesterol and low density lipoprotein.. What is the mechanism of action of this drug which increase these types of lipid...
Effect of Sulfa Drugs on Lipid Profile
1. Sulphonylurea group of antidiabetics increase Triglycerides compared with Insulin in diabetic patients (1).
2. Thiazide group of diuretics, mainly used in patients with hypertension, increase the TG, LDL-C, and VLDL-C in a dose dependent manner, although Indapamide is devoid of these dyslipidemic effects of other thiazides. (2-5)
1. Article Comparison of lipid profiles and lipoprotein (a) levels in p...
2. Article The Effect of Thiazide Diuretics on Blood Lipid Profile in H...
3. Article Effect of diuretics on the plasma lipid profile
4. Article Diuretics and β-blockers: Is there a risk for dyslipidemia?
5. Article Effects of indapamide versus hydrochlorothiazide on plasma l...
Possible mechanism of dyslipidemia due to Thiazide diuretics
The mechanisms of diuretic-induced dyslipidemia remain unclear, but may be related to worsened insulin sensitivity and/or reflex activation of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system in response to volume depletion. This particularly occurs when larger doses of thiazides are used, and is less likely to occur with smaller doses.
For details have a look at this medscape article.
Diuretic-Related Side Effects: Development and Treatment
https://www.medscape.com/viewarticle/489521_9
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