Prolonged exposure to heavy metals such as cadmium, copper, lead, nickel, and zinc can adversely affect the human health by causing cancer, encepalopathy, peripheral neuropathy, gastroenteritis, anaemia, renal tubular acidosis, ventricular arrhythmias, intestinal hemorrhage, emphysema, pulmonary edema, osteomalacia, dystonia, polyneuropathy, dermatitis, hyperkeratosis, polyneuritis etc. Please take a look at the following useful references.
Article Heavy Metal Toxicity and the Environment
Article Toxicity, mechanism and health effects of some heavy metals
Article An Overview of Carcinogenic Heavy Metal: Molecular Toxicity ...
Article Heavy Metal Causing Neurotoxicity in Human Health
Chapter Heavy Metals and Cancer
Sir, there are many lethal effects due to heavy metals toxicity. They incorporate themselves in our CNS, lungs, digestive tract etc. Causing Anemia like symptoms. Nausea, headache, and if become chronic then dangerous for patients. Lead to death.
Thankyou.
I have attached several articles on the influence of heavy metals on the environment.
actually its a talkative ans, rather, you should read some journal article. @ Enrique Reynaldo de la Cruz had some good examples. you can have it to find your desired ans. Thanks.
Excess heavy metal consumption in different forms via different track causes multiple diseases ranging from chronic to acute. The heavy metals in fatty tissues take part in metabolic process of food chain and occupy permanent space in creature body. The damage is proportional to the quantum of heavy metals and its damaging potential.
The major effects of metals occur at a cellular level. Inside cells, metals can generate free radicals and disrupt cell functioning by binding to the functional sites of proteins. Many of the toxic metals alter the functioning of DNA polymerase, an enzyme responsible for the repair of damaged DNA (Sanders et al. 1996).
Sanders, B.M., Goering, P.L., Jenkins, K., 1996. The role of general and metalspecific cellular responses in protection and repair of metal induced damage: Stress proteins and metallothioneins, in: Chang, L.W. (Ed.), Toxicology of Metals. CRC Press, New York, pp. 165-187.
There are heavy metals in trace concentrations (less than 10 ppm with less than 10 ppm) in different metals. Their biological availability is influenced by physical factors like temperature, phase association, adsorption and sequence. It is also affected by chemical factors, which have biological effects on thermodynamic balance, composition kinetic, lipid solubility etc. Biological factors such as species characteristics, traffic contact and biochemical / physical adaptation also play an important role.
In general, the toxicity of metal ions for mammals is due to the chemical reaction of the ions with cellular structural proteins, enzymes and membrane systems. The target organ of specific metal toxicity is usually those organs that accumulate the highest concentration of the metal. This often depends on the exposure route and the chemical compound of the metal.
For the example,
Useful link: http://granthaalayah.com/Articles/Vol3Iss9SE/152_IJRG15_S09_152.pdf
Authoritative Source: https://toxnet.nlm.nih.gov/ and then https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm (Hazardous Substances Data Bank)
Dear Mohsin,
Kindly go through the attached files and the link below.
https://www.degruyter.com/downloadpdf/j/intox.2014.7.issue-2/intox-2014-0009/intox-2014-0009.xml
Best regards.
Hello Mohsin
When high amounts of heavy metals enter the body, they accumulate in the kidneys, liver, bone and brain, which disrupt the functioning of that part of the body. Some heavy metals are carcinogenic and some only affect the body's ability to produce red and white cells. In fact, any heavy metal affects the body or parts of the body. For example, a heavy metal may not cause any side effects by contacting the skin, even when swallowed, there is no serious damage, but the vapor burning of that heavy and toxic metal causes severe damage to the lung.
- Hazards of heavy metal contamination.pdf143.02 KB
- Heavy metal pollution and human biotoxiceffect.pdf110.88 KB
The effect of heavy metals in the component of environmental is causes severe toxicity and damage to multiple organs especially when accumulated at high level in human body.
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