Fluoride provides evidence of impairing mitochondrial energy production. What is the mechanism? Is fluoride involved in the switch from aerobic to anaerobic respiration?
Fluorine is unsurpassed in its 'hunger' for electrons. Is fluoride at the root of degenerative disease? Are we observing a singular vector expressing in different cells in glands, organs, and tissues? Is the damage to the cell membrane from fluoride observable through microscopy? Dr. AK Susheela did beautiful work with SEM on tooth surfaces, do other cells suffer the same damage?
Fluoride acts as a nonspecific phosphatase inhibitor. In mitochondria, fluoride inhibits pyruvate dehydrogenase phosphatases (PDP's). This prevents activation of pyruvate dehydrogenase and impairs further oxidation of pyruvate.
@Kenneth - your answer is extremely helpful and greatly appreciated. The mechanism you describe cripples the Kreb's cycle, in other words. Would you please provide a citation? Thank you again.
I don't know of any evidence that concentrations of fluoride found in drinking water affect metabolism. At high concentrations, fluoride is a nonspecific sereine/threonine phosphatase inhibitor. https://www.neb.com/products/p0759-sodium-fluoride-fluoride
From personal experience, fluoride added to isolated mitochondria prevents pyruvate dehydrogenase activation by maintaining the enzyme in the phosphorylated state. Pyruvate usage is blocked but the Krebs cycle can be maintained by other anaplerotic reactions.
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