For example what's the difference between these 4 microRNAs?
hsa-miR-101*
hsa-miR-101
hsa-miR-101-3p
hsa-miR-101-5p
Which pairs (if) are the same? Which pairs are the same in sequence?
hsa-miR-101* comes from the same hairpin miRNA of hsa-miR-101, but hsa-miR-101* is less predominant than hsa-miR-101(from the opposite arm of the precursor). If there is no sufficient data to determine which sequence is the predominant, they are named as miR-101-5p (from the 5' arm) and miR-101-3p (from the 3' arm).
Also an older convention sometimes used miR-142-s and miR-142-as.
The miRNA* nomenclature indicates a miRNA that originates from the same hairpin structure (pri- and pre-miRNA) of the "main" miRNA and it supposed to be complementary to the "main" miRNA.
Someone else asked this question some weeks ago. Check the link
https://www.researchgate.net/post/Whats_difference_between_hsa-let-7a-5p_hsa-let-7a-3p_What_do_5p_3p_refer_to?#view=51854976d11b8bcd5c000033
hsa-miR-101* comes from the same hairpin miRNA of hsa-miR-101, but hsa-miR-101* is less predominant than hsa-miR-101(from the opposite arm of the precursor). If there is no sufficient data to determine which sequence is the predominant, they are named as miR-101-5p (from the 5' arm) and miR-101-3p (from the 3' arm).
Also an older convention sometimes used miR-142-s and miR-142-as.
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