What is the correlation of protein denaturation with aging in cells/tissues?

09 September 2015 1 2K Report

Medical Biochemictry, Protein Biotechnology

I am not an expert on this issue, but in my understanding, all protein genes acquire some spontaneous mutations during aging, and at some point those mutations start affecting the normal (regular) conformations (or enzymatic activity) of their proteins (denaturation) during biosynthesis resulting in higher percentage of the proteins not matching to the requirements of the cellular ER quality control. As a result, more proteins are directed to lysosomes (for disposal) as the proteins not capable to exert their physiological functions (instead of being secreted or performing their physiological roles inside the cell). And that results in the physiological defficiency of each particular protein function that might accelerate the cell death.

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