It has recently been reported that Axin2-positive peri-central vein hepatocytes correspond to the stem/ progenitor cells of the uninjured liver tissue (Nature 2015. doi:10.1038/nature14863). Wnt signal is positively correlated with self-renewal and maintenance of “stemness” with chromosomal/ genetic stability with diploid.  As liver cells undergo differentiation, they acquire the polyploidy and the level of canonical Wnt/beta-catenin signal activity gradually decreases.

On the other hand, zonation of the lobule shows the heterogeneity. The zonation of gene expression resulting in the different cellular equipment of liver cells with enzymes, translocators and subcellular structures is regulated mainly at translational level. In the dynamic zonation of carbohydrate metabolizing enzymes, gradients in oxygen and in the glucagon/insulin ratio decreasing from the periportal to the perivenous area appear to be major effectors. 

That is why I think higher Wnt signal induces the enzymes related to glycogen synthesis and OXPHOS in mitochondria, whereas lower Wnt signal results in the enzymes contributing to the glycolysis, lipogenesis and ketobiotic metabolism.

I am appreciated if you would be kind enough to give me some suggestions and have an open discussion.

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14863.html