In Caucasians, bilirubin is manifested by jaundice skin pigmentation when its serum levels > 50 umol/L, mostly > 80 umol/L. What about Japanese, Hispanic or African population and how do you detect it (sclerae pigmentation? probably around 100 umol/L?) As European, I have no experiences with these populations, thank you for your experience.
It is not difficult to extract the bilirubin signal from light reflected by the skin - you simply have to correct for melanin pigmentation. There are many papers in the literature. if you want me to say more then let me know.
The complication comes when you do "blue" light therapy for melanocompetent subjects because blue light stimulates an immediate pigment response which unfortunately is somewhat different from native pigment. It gets tricky but not impossible - don't get discouraged.
Thank you, Dr. Kollias! I`m not a clinican - I was doing genetics of hereditary hyperbilirubinemias, but want to know more background - if you can point a few key papers, that would be great!
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