What is the experimental water-octanol partition coefficient of cholesterol?

Please, send a paper on this subject If you have or know about It.

08 September 2018 8,208 0 View

Can anyone suggest a literature about small interference RNA (siRNA)?

I am interested in leaning about the structure prediction and design, molecular mechanisms and biological functions of siRNA, gene silencing (in special the PTK7 gene), and transfection using...

07 August 2018 3,214 6 View

What is the most suitable PEG for encapsulating peptides in order to reach the alveoli regions by inhalation?

I would like to make PEG-peptides nanoparticules to reach the alveoli regions by inhalation.

06 July 2018 2,594 1 View

What is the reproducibility of the umbrella sampling for calculating free energies in order to estimate the oil-water partition coefficient?

The calculation of the free Gibbs energy of transferring a molecule from the aqueous phase to octanol phase (or vice versa) by using umbrella sampling in order to estimate the oil-water partition...

05 June 2018 2,023 0 View

How to build reduced coarse grained models for phospholipids with two ir three beads?

Please, tell me any good paper or web site to download models.

04 May 2018 6,176 1 View

Have you worked with beta-defensin-3 as an antimicrobial agent? What is its effect in the lung surfactant?

I am interest in getting more information on the interaction of beta-defensin-3 with lung surfactant and bacteria.

03 April 2018 6,614 0 View

Have you worked with Naringenin and Naringin as antimicrobial agents? What is the effect of their interaction with lung surfactant and bacteria?

I am interested in getting more information about this subject.

03 April 2018 4,114 0 View

How can I perform error analysis in umbrella sampling simulations?

Do you have any program to evaluate the statistical error in umbrella sampling?

01 February 2018 3,488 0 View

Has anyone encapsulated antimicrobial peptides for drug deliever to lung?

Please, let me know any procedure or paper about this subject.

07 August 2017 1,371 3 View

What are the best materials for drug encapsulation to deliever into Lung?

Please, send me literature about It.

07 August 2017 9,939 2 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How to remove fatty material from plant extract?

The resultant solid was partitioned three times with 250 ml of petroleum ether (40-60/c) to remove any fatty material and evaporated to dryness.

28 February 2021 9,464 2 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

I have a problem with kanamycin - why the kanamycin doesn't affect?

Hi everyone, I need to expression of GFP with pET28 plasmid in E. coli BL21(DE3) plysE. Transformed cells have kanamycin and chloramphenicol resistance. Normally, only transformed cells should...

22 February 2021 4,032 4 View

Does anyone have any ideas why drug-resistant malaria is increasing in Southeast Asia even when those drugs are no longer used?

When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...

21 February 2021 6,084 5 View

What is the most prevalent drug related problem in the developed countries?

Detecting the drug related problems is an important step in the pharmaceutical care plan

21 February 2021 5,421 3 View

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19 February 2021 8,647 3 View

How to improve dissolution of neosome?

I have made neosome from herbal drug. Neosomes are stable. But I face problems in dissolution. I used minimum ratio of 1:1:0.25 ( Drug:span 60: Cholesterol and GMs. Now how can I active better...

17 February 2021 3,584 1 View

Can 5-FOA Diffuse Through Agar?

I am preparing to do a gene knockout in the filamentous fungi Coccidioides posadasii targeting pyrG/URA3 so that 5-FOA can be used for selection pressure instead of traditional antibiotic...

16 February 2021 169 4 View