Andre Silva Pimentel

20 Questions 28 Answers 0 Followers

Questions related from Andre Silva Pimentel

What is the experimental water-octanol partition coefficient of cholesterol?

Please, send a paper on this subject If you have or know about It.

09 September 2018 8,264 0 View

Can anyone suggest a literature about small interference RNA (siRNA)?

I am interested in leaning about the structure prediction and design, molecular mechanisms and biological functions of siRNA, gene silencing (in special the PTK7 gene), and transfection using...

08 August 2018 3,269 6 View

What is the most suitable PEG for encapsulating peptides in order to reach the alveoli regions by inhalation?

I would like to make PEG-peptides nanoparticules to reach the alveoli regions by inhalation.

07 July 2018 2,647 1 View

What is the reproducibility of the umbrella sampling for calculating free energies in order to estimate the oil-water partition coefficient?

The calculation of the free Gibbs energy of transferring a molecule from the aqueous phase to octanol phase (or vice versa) by using umbrella sampling in order to estimate the oil-water partition...

06 June 2018 2,074 0 View

What is the best suitable method for measuring the partition coefficient logP (or distribution coefficient, logD) for ionizable compounds (drugs)?

Potentiometric or HPLC?

05 May 2018 8,348 0 View

How to build reduced coarse grained models for phospholipids with two ir three beads?

Please, tell me any good paper or web site to download models.

05 May 2018 6,220 1 View

Have you worked with Naringenin and Naringin as antimicrobial agents? What is the effect of their interaction with lung surfactant and bacteria?

I am interested in getting more information about this subject.

04 April 2018 4,173 0 View

Have you worked with beta-defensin-3 as an antimicrobial agent? What is its effect in the lung surfactant?

I am interest in getting more information on the interaction of beta-defensin-3 with lung surfactant and bacteria.

04 April 2018 6,668 0 View

How can I perform error analysis in umbrella sampling simulations?

Do you have any program to evaluate the statistical error in umbrella sampling?

02 February 2018 3,540 0 View

What are the best materials for drug encapsulation to deliever into Lung?

Please, send me literature about It.

08 August 2017 9,993 2 View

Who is interested in collaborating on antimicrobial peptides?

I am interested to collaborate with a group able to synthesize antimicrobial peptides important to Lung infections.

08 August 2017 6,475 0 View

Has anyone encapsulated antimicrobial peptides for drug deliever to lung?

Please, let me know any procedure or paper about this subject.

08 August 2017 1,419 3 View

Why are antimicrobial peptides inactivated by surfactant?

Many in vivo tests show antimicrobial peptide (and other antibiotics) are inactivated by surfactants (lung surfactants). Some studies explain the antimicrobial peptide strongly binds to the lung...

07 July 2017 2,758 5 View

How to calculate the Walter/octanol coefficient of a drug using umbrella sampling?

I am trying to use the wham method.

04 April 2017 8,421 0 View

What is the octanol/Walter coefficient of the antimicrobial peptide LL-37?

LL-37 is an important peptide that may be used as pneumonia treatment.

04 April 2017 5,477 0 View

What is the octanol/Walter coefficient of the peptide KL4?

KL4 is a hydrophobic peptide that mimics the Lung surfactant protein.

04 April 2017 7,032 0 View

How can I calculate the water/octanol partition coefficient using umbrella sampling and molecular dynamics?

I tried to use molecular dynamics to calculate the free energy of transfering a molecule from water to octanol phase. I used the umbrella sampling to sample the transferring path.

04 April 2017 2,588 10 View

I am looking for a young researcher interested in joining my research group. Who is interested in?

Gromacs simulation of lung surfactant modelos using atomistic or coarse grained molecular dynamics. Theory and Experiment. Send your resume If interested. The prospective researcher must have...

02 February 2017 3,906 0 View

Who works with antimicrobial peptides used as antibiotics to treat lung infections?

Trying to make connections!!!

01 January 2017 3,973 5 View

Is sodium cholate a good materials for drug encapsulation to deliever into Lung?

Any good idea about the toxicity of sodium cholate in the lung?

01 January 1970 5,811 4 View