Has anyone encapsulated antimicrobial peptides for drug deliever to lung?

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What is the experimental water-octanol partition coefficient of cholesterol?

Please, send a paper on this subject If you have or know about It.

08 September 2018 8,295 0 View

Can anyone suggest a literature about small interference RNA (siRNA)?

I am interested in leaning about the structure prediction and design, molecular mechanisms and biological functions of siRNA, gene silencing (in special the PTK7 gene), and transfection using...

07 August 2018 3,301 6 View

What is the most suitable PEG for encapsulating peptides in order to reach the alveoli regions by inhalation?

I would like to make PEG-peptides nanoparticules to reach the alveoli regions by inhalation.

06 July 2018 2,689 1 View

What is the reproducibility of the umbrella sampling for calculating free energies in order to estimate the oil-water partition coefficient?

The calculation of the free Gibbs energy of transferring a molecule from the aqueous phase to octanol phase (or vice versa) by using umbrella sampling in order to estimate the oil-water partition...

05 June 2018 2,110 0 View

How to build reduced coarse grained models for phospholipids with two ir three beads?

Please, tell me any good paper or web site to download models.

04 May 2018 6,258 1 View

What is the best suitable method for measuring the partition coefficient logP (or distribution coefficient, logD) for ionizable compounds (drugs)?

Potentiometric or HPLC?

04 May 2018 8,383 0 View

Have you worked with beta-defensin-3 as an antimicrobial agent? What is its effect in the lung surfactant?

I am interest in getting more information on the interaction of beta-defensin-3 with lung surfactant and bacteria.

03 April 2018 6,703 0 View

Have you worked with Naringenin and Naringin as antimicrobial agents? What is the effect of their interaction with lung surfactant and bacteria?

I am interested in getting more information about this subject.

03 April 2018 4,208 0 View

How can I perform error analysis in umbrella sampling simulations?

Do you have any program to evaluate the statistical error in umbrella sampling?

01 February 2018 3,575 0 View

What are the best materials for drug encapsulation to deliever into Lung?

Please, send me literature about It.

07 August 2017 10,036 2 View

How to increase simulation box size?

We intend to study the interaction between peptides and polymer (like PP, PE and PS) through MD simulations using Martini force fields ( Martini 2 for PP and Martini 3 for PE, PS). We have...

08 August 2024 4,842 0 View

Separation of organic acids-HPLC?

Hello What should be done to separate and identify organic acids in HPC when their RetTime is the same?Like oxalic acid with Propanoic Acid.or acids that have a very close RetTime.

07 August 2024 8,782 3 View

Unusual intensity drop in some sections of chromatograms in DDA?

Hi, we have measured tryptic peptides using both DDA and DIA method on QExactive. In DDA replicates i saw unusual intensity drops occurring at the same sections of chromatograms in DDA replicates...

07 August 2024 3,218 4 View

The aqueous fraction of the hydroethanolic extract is showing the presence of palmitic acid. What is the mechanism responsible ?

Palmitic acid presence in aqueous fraction

05 August 2024 8,624 4 View

How to analyze multiple phosphorilation sites?

Hello, I am currently analyzing some phosphoproteomics data, but I have peptides with multiple phosphorylation sites or phosphorylations together with carbamidomethylation or oxidation. How can I...

04 August 2024 8,432 3 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...

03 August 2024 2,730 1 View

How to convert g/kg Humic acid dose to kg/ha?

I used humic acid at 0.044 g/kg soil in my pot experiment. But finally, I have to recommend kg/ha. Each pot's soil weight was 11 kg. What is the solution?

02 August 2024 7,186 6 View

Recovery rate after peptide desalting using Sep-pack C18 1 cc Vac Cartridge?

Recently I'm trying to use Sep-pack C18 1 cc Vac Cartridge (Waters: SKU: WAT054955) to desalt digested peptides. However, the recovery rate is usually 40-60%. What is the normal recovery rate?

31 July 2024 6,544 11 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Why is trifluoroacetic acid (TFA) used in c-18 column?

I would like to know the role of the TFA (trifluoroacetic acid) used on reverse phase chromatography c-18 column. It's is often used with a concentration of 0.1% on the mobile phase.

23 July 2024 8,075 3 View