For my case, I always use mature hippocampal neurons for monitoring neuronal plasticity. They are easy to handle, and the morphological change of dendritic spines is quite obvious.
Dear Selma,
I published the paper: Sil'kis IG. A possible mechanism for the effect of neuromodulators and modifiable inhibition on long-term potentiation and depression of the excitatory inputs to hippocampal principal cells. Neurosci Behav Physiol. 2003; 33(6):529-41. Review.
You can find pdf file in my page in ResearchGate or in the attachment. There is a Table 1. Effects of Neurromodulators on the Extent of Long-Term Potentiation and Depression of Excitatory and Inhibitory Inputs to Inhibitory Interneurons and Their Target Cells.
Using this Table you can predict the result of action of any neuromodulator on LTP of synaptic efficacy in the neocortex and hippocampus if you know what kind of receptors are influenced by applied drug. Neuronal plasticity is not directly correlated with the plasticity of synaptic inputs since different inputs to the same neuron may variously influence its activity.
Isabella
Hippocampal neurons will be easy to assess the neuronal plasticity (i.e. neuron structure, spine morphology and density) . Though, dentate granule neurons, CA3 and CA1 neurons will have difference impact based on their functions. Meaning, DG neurons may be sensitive to certain concentration or types of drugs that CA1 neurons won't be. If you are using in vitro system, then mouse cortical neurons will be your best bet.
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