Firstly, the model will not be a PCOS model, it will be a PCO model because the first thing you monitor will be its ovary. I am sure you have come across Estrogenized or Androgenized models, where they call it a PCOS model. Please understand that the two are very different phenomena. You have to do a lot of histology studies, hormone assays in the sera etc. to validate if the model is close to PCO phenotype. The syndrome as a whole is very difficult to be reproduced in animal models and is a whole project of 3-4 years at the minimum. Depending on what parameters in PCO model you want to study you can induce prenatal androgenization or estrogenization.
Hi there. So, as Pooja said, there is no ideal model to study PCOS - all of them have benefits and flaws. The most used ones are based on androgen therapy, especially during prenatal/neonatal periods. Others use genetic models and so on. However, these are rather expensive models that sometimes aren't available in places with low resources (we are currently facing this problem in Brazil). If you're looking for an effective and cheap model to study the metabolic pathways leading to PCOS, i.e. hyperinsulinemia, obesity and metabolic syndrome, then you might be interested in a paper we published last year. This is a model based on neonatal injections of this compound called MSG, often used as a food additive. If you have more questions or ideas, please send us a message. I'm always glad to talk about science! Hope this helps!
Article Reproductive alterations in hyperinsulinemic but normoandrog...
Estradiol valerate 4 mg /kg single dose ,with daily vaginal smear for 64 development of PCO in rat
Dr Shukrya Alwan
The Dr Tariq Khan says that SD rats are the best for such experiments! contact him for more details
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