Can anybody please suggest me about the measures that are to be considered to decrease the death rate in benzene treated wistar rats.. And the preferred oral dose of benzene to induce aplastic anaemia in the same..
Benzene is usually given by ip doses or via inhalation. I am not sure about oral doses of benzene.
Benzene (as highly lipid soluble product) has very poor oral absorption, so you can use i.p or inhalation rout.
How much dose for it?
Hi try to this link, you'll find this paper
Overview of benzene-induced aplastic anaemia.
Regards
http://www.ncbi.nlm.nih.gov/pubmed/8987251
Can anybody please provide me the in vivo toxicity studies for an isolated compound? Please include the procedure of calculating LD50 and duration of the study.
04 May 2016 4,633 0 View
what is the best animal model to induce PCOS in rats?
06 July 2014 8,653 8 View
What are the laboratory methods available to measure intraovarian and intra abdominal pressure in rats?
06 July 2014 6,302 1 View
I want to measure the rat serum levels of testosterone, estrogen, progesterone, FSH and LH. Can anybody please suggest me the available cost effective methods including ELISA kits?
06 July 2014 5,558 4 View
Importance of crystal sugar in Ayurvedic preparations.
02 March 2013 7,990 4 View
Can anybody suggest methods of induction of aplastic anaemia in rats?
02 March 2012 4,465 7 View
Can benzene cause siezures in rats and thus cause sudden death of an animal?
02 March 2012 1,344 3 View
Methods available for inducing breast ,intestinal throat and cancer and leukaemia.. In rats or mices..
31 December 2011 6,771 9 View
I have extracted essential oil from a medicinal plant and want to make several concentrations for some biological activities (Antidiabetic assay). How can i prepare the several concentrations to...
04 July 2024 8,100 4 View
I have nearly completed my preparation for the short communication. However, I could use some assistance with the results. Any help would be greatly appreciated.
12 June 2024 4,230 1 View
Understanding and Managing Constipation: A Comprehensive Rev... Can you explain the treatment options for adult constipation, including both non-pharmacological and pharmacological approaches?
24 May 2024 8,259 3 View
What pharmacological agents are used in the treatment of DI, and how do they work?Advances in Understanding and Management of Antidiuretic Hor...
08 May 2024 8,585 1 View
Are there any specific considerations for the dosing and administration of dexmedetomidine in patients with renal or hepatic impairment?Dexmedetomidine: A Comprehensive Review of Pharmacology,...
08 May 2024 1,747 1 View
Can you explain the pharmacological mechanism of action of dexmedetomidine and how it differs from other sedativesDexmedetomidine: A Comprehensive Review of Pharmacology, Cli...
08 May 2024 2,755 2 View
. What are the FDA-approved indications for dexmedetomidine, and how have its off-label uses expanded over time?Dexmedetomidine: A Comprehensive Review of Pharmacology, Cli...
08 May 2024 9,245 1 View
I would like to understand the calculation of % enzyme inhibition
28 April 2024 4,359 1 View
Methods are based on Chel-Guerrero and colleagues'Phytochemical Profile, Toxicity, and Pharmacological Potenti... . We use a 1M Tris buffer with pH of 6.8, with Bovine Serum Albumin as the...
25 April 2024 8,802 0 View
Understanding Pain Physiology: Foundations for Effective Chr... Multidisciplinary pain management approaches involve the collaboration of various healthcare professionals from different...
19 April 2024 6,268 1 View