Should I use Non-Compartmental Analysis or Compartmental Analysis? If Compartmental analysis, should it be 1or2 compartment model and why?
Dear Showande Johnson Segun,
In a recent study conducted on pharmacokinetic analysis of Simvastatin a two-compartment model was chosen as the final disposition model for simvastatin pharmacokinetics based on the OFV changes and GOF plots after testing one through three compartment models. The group tested various absorption models to describe the atypical, simvastatin concentration profile during absorption phase.
For more on this study, please see attached file.
Hoping this will be helpful,
Rafik
Thanks Rafik, will go through the document and revert if I have further questions
Dear Showande,
Recently the compartmental pharmacokinetic analysis has achieved the great height, now many computational systems are available that includes whole body and calculates you the pharmacokinetics of any drug as it like a human body. Systems are available that have as many as 18 or more physiological compartments in it. One of this PK-Sim of Bayer technology Services Gmbh. You can go to the link
www.systems-biology.com
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