I have formulated a nanoemulsion formula consisting of oil, surfactant, and co-surfactant to be used as a carrier for a low-water-soluble drug in an oral formulation. However, I am unsure about which dilution would be best for characterizing and optimizing the droplet size. If I make a series of dilutions and measure the droplet size, which one should I select? What are the conditions for choosing the appropriate dilution? Thank you for your help.
Sarmad Alrekabi
Microemulsions begin to form after the ratio [H2O]/[AOT]=4-10 for the water/iso-octane/AOT system. For your system, this can be determined by water activity vs. [H2O]/[AOT], by turbidity with a nephelometer, by NMR. See Chapter 5 of my monograph
Book Aqueous Hydrocarbon Systems in Science and Engineering
If the dilution step don't modify the droplet size, you can do the dilutions and see which is the measurement with the best quality of parameters (Good result, high intercept, low PdI,..)
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