i have formulate a nano-emulsion as a drug carrier ,consist of oil,surfactant and co surf. , upon mixing different ratios of oil,SA,CoSA the hydrodynamic measurment is about 20-30nm (average of three readings) but have occured three peaks first one is matched to hydrodynamic diameter(20-30nm) but the other two are large ? so,how to make it unimodal (one peak) and if it impossible , whta is the size of my particle ?
Regards
Hi Sarmad Alrekabi
In your question, you mentioned presence of 3 peaks in your particle sizing data. Each peak indicates one population of particles or contaminants / impurities.
In order to make your particle size monomial generally extrusion or sonication techniques are used. Refer to the attached paper for comprehensive explanation.
Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems.
M Danaei, M Dehghankhold, S Ataei, F Hasanzadeh Davarani, ...
Pharmaceutics, 2018, 10 (2), 57.
Received: BEST PAPER AWARD***
Sarmad Alrekabi
Your results are similar to our experiments with dodecyl sulfate solution
Article Structure of Micelles of Sodium Dodecyl Sulphate in Water: a...
The evaluation and measurement of nanoemulsion include particle size, electric potential. morphology,and physical stability. The stability of the nanoemulsion is affected by the droplet size, which is determined by mean droplet size (Z-diameter) and polydispersity index (PDI).
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