hello every one, and thanks in advance for help,
i working on SMEDDS , and the principle is mixing of oil,SAa and Co-SA( chosen from solubility capacity for the required compound to be loaded on) in different ratios to produce transparent emulsion after characteization done,the question is , how can i predict the selected oil, SA and CoSA regarding solubility basis, will develop a well SMEDDs ? is it just error trial , or there is a specific HLB value required to considerate?
Sarmad Alrekabi
You need to take into account the specific value of NLB only for the selection of surfactants. Moreover, SA and CoSA oils should be approximately equal in hydrophobicity to hydrocarbons. The remaining components and their ratio you need to select experimentally.
Sarmad Alrekabi
I repeat that HLB refers to surfactants. Mixtures of surfactants with various HLBs are selected experimentally. The oil does not have HLB.
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