I would like to seek help in finding the best animal model to study ear infections and diseases so that these can be addressed using nanotechnology.
Dear Zorada, Isabelle Chemin is correct, it really depends on many factors. In my experience as a veterinary pathologist, many if not most guinea pigs tend to have acquired otitis media at the time of diagnostic necropsy. They have relatively large tympanic bullae and large tympanic membranes. Chincilla's are a great model for administering products because of their dorsal as well as ventral compartment to their extensive tympanic bullae system. However, their auditory ossicles differ greatly from people and people do not have tympanic bullae. Finally, the mongolian gerbil is the commonly used animal model for cholesteatomas (aural keratin cysts) which is commonly associated with otitis media in people and dogs.
Fine answer from Brad, from my side it seems that nobodies used non-human primate for this purpose but in the opposite use the knowledge of ear human disease to cure NHP in case of problem in zoo ;-)
except perhaps in this paper i found in Pubmed: Laryngoscope. 2005 Aug;115(8):1469-72.
Mucosal biofilm formation on middle-ear mucosa in a nonhuman primate model of chronic suppurative otitis media.
Dohar JE, Hebda PA, Veeh R, Awad M, Costerton JW, Hayes J, Ehrlich GD.
Source
Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh, 3705 5th Avenue, Pittsburgh, PA 15213, USA. [email protected]
And finally this latter one in which using larger animal like macaca, like the previous one, you can also use chirurgical approach together with the chemical one. But this sorts of model should be limited to a true pre-clinical assay.
Eur Arch Otorhinolaryngol. 2012 Jan 5. [Epub ahead of print]
Promontorial cochleostomy in nonhuman primates. Is it atraumatic?
Manrique R, Picciafuoco SE, Cervera-Paz FJ, Pérez N, Manrique MJ.
Source
Department of Otolaryngology, University of Navarra Hospital & Medical School, Pio XII s/n., Pamplona, Navarra, 31008, Spain, [email protected].
Dear everyone,
Thank you very much for you active participation. I appreciate all your input.
Pierre, I will definitely check the references that you have provided.
Brad and Isabelle, in particular, is there a model animal for the delivery of steroids through the ears? If there are similar publications that you know of, I would greatly appreciate know what they are.
Pierre, What animal is popularly used for SSHL? I read some used sheep and guinea pigs...is one better than the other and why?
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