I am looking for the effective amount of Trastuzumab that is responsible for killing the breast cancer cells in Humans
When patients with metastatic breast cancer were administered trastuzumab at a loading dose of 4 mg/kg followed by a weekly maintenance dose of 2 mg/kg, the typical clearance of trastuzumab was 0.225 l/day and the typical volume of distribution was 2.95 l, with a corresponding terminal half-life of 28.5 days
(95% confi dence interval, 25.5–32.8 days).
Check out the doses used in different clinical trials and try those doses for your study. I think you must take into consideration the lethal dose too before using in your experiment.
Thank you for your comments, however I reiterate that I need the effective concentration of Herceptin to kill/inhibit tumor growth. The serum concentration does not tell me how much is effective. I wish to know if there exist any paper where authors measured the "amount" of herceptin/trastuzumab in the human tumors after systemic injection of herceptin. I am asking this because if I wish to "in a way" inject trastuzumab directly to tumors, what is the amount of trastuzumab I should inject.
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