Therapy of MAC infections of non-HIV patients is difficult (1). When you have across the board resistance as your question indicates, any current therapy is probably ineffective. When all else has failed and there is nothing available, one can treat the patient under compassionate basis that will improve quality of life and perhaps, bring about some relieve, if not a cure. We have shown that the use the old neuroleotic thiordazine will improve the quality of life of XDR TB patients and has been recommended as a salvage drug (2). In vitro, small quantities of thioridazine will render MAC strains susceptible to many second line drugs to which the strain was initially resistant (3). The positive in vitro responses are opined to be the result of inhibition of over-expressed efflux pumps which extrude the antibiotics before they reach their intended target (4). I suggest these cited papers for more complete info.