Leonard Amaral

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Questions related from Leonard Amaral

Thioridazine cures mice of antibiotic susceptible and MDR TB infections and cures XDR TB patients so why not use it now?

Thioridazine is cheap, and it inhibits the replication of all encountered Mtb strains regardless of their antibiotic resistance status , it enhances intracellular killing of MDR Mtb and XDR Mtb ,...

28 November 2013 3,025 2 View

Are those infected Mtb human subjects that do not develop active disease infected with a benign strain?

Strangely enough, the isolation of Mtb and analysis of its genome from autopsy subjects who do not present with active disease, has not been a subject of investigation. Because a parasite does not...

15 November 2013 5,813 36 View

Is there more than one mycobacterium tuberculosis strain infecting an individual?

From discussions with colleagues, I get the impression that a single TB infection involves a single strain. This cannot be unless there is a preventive mechanism that renders the acquisition of...

15 November 2013 4,002 7 View

Are efflux pumps of bacteria the means by which all secretions from the bacterium take place?

The first response of bacteria to a noxious agent such as an antibiotic is the induced over expression of efflux pumps. Once the threat of the noxious agent passes, the level of efflux pump...

28 June 2013 2,792 4 View

Do steroid receptors of responding eukaryotic cells share antigenic determinants with their respective steroid binding plasma proteins?

Transcortin is the plasma protein that specifically recognises cortisol. Forty years ago with a series of studies, we made a transcortin specific antibody that also recognised cortisol binding...

11 June 2013 2,166 0 View

Can specific lasers matched to the energy level of a molecule create new molecules not readily made by conventional organic chemistry methods?

We have exposed a number of bioactive pure compounds to lasers of a given nm wavelength and energy level for varying periods of time, followed the result of exposure via thin layer chromatography,...

28 May 2013 573 1 View

Do all cell receptors that recognise cortisol share a common antigenic determinant?

Over 30 years ago my studies indicated that placenta, breast cancer and lymphocytes contained intracellular proteins that bound and recognized cortisol as transcortin the cortisol binding protein...

24 May 2013 1,645 0 View

Is any member of ResearchGate interested in the curing of XDR and TDR TB infections?

We have shown that thioridazine promotes the killing of MDR and XDR Mtb by non-killing human macrophages and have also demonstrated the mechanism of action.

02 January 2013 6,925 2 View