We have RO station produce purified water of conductivity less than 1.5µs/cm.
will be any problem if i use it for HPLC analysis after filter it through 0.22 micron filter
Not really (depends on the sensitivity of your detector). You should also have a TOC meter online to detect and destroy any organic molecules. I assume you have performed blank injections with this water and demonstrated it does not interfere in your analyses.
Not really (depends on the sensitivity of your detector). You should also have a TOC meter online to detect and destroy any organic molecules. I assume you have performed blank injections with this water and demonstrated it does not interfere in your analyses.
To answer your question, please refer to this linked article: "What type of Water Should I use for HPLC, UHPLC or LC/MS Analysis".
http://hplctips.blogspot.com/2013/10/what-type-of-water-should-i-use-for.html
Make sure you aren't seeing ghost peaks from any dissolved organics. Also, buy some LC-MS grade water to verify it will work with other water. That is less of a concern if you buffer the solvents.
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