CD23, also known as Fc epsilon RIII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels

CD23, also known as Fc epsilon RIII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites

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The protein encoded by this FCER2 gene is a B-cell specific antigen, and a low-affinity receptor for IgE. CD23 has essential roles in B cell growth and differentiation, and the regulation of IgE production. CD23 also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

t may be possible to develop a strain of T. canis in which the gene for production of the protein similar to CD23 is

inactive. Experimental animals might be infected with these worms and then inoculated with high levels of a soluble

form of CD23 which would bind up a large fraction of the available IgE. Since there would be little IgE available to

bind to the surface of the worms, any rapid destruction of the worms relative to controls could be attributed to the

inability to disguise themselves as “host like” rather than their ability to neutralize the effects of IgE.

An alternative would be to develop monoclonal antibodies against the Fc portion of the IgE antibody and administer

this to infected experimental animals that normally harbour the parasite. If the worms are destroyed it suggests that

the monoclonals interfered with the ability of the CD23-like protein to bind IgE Fc regions, and that it is Fc binding

that explains the protective value for the CD23-like protein for the parasite.