Weather these enzymes which are involved in Cancer lipid metabolism are the causative genes for the cancers or just they are supplying the required energy for rapid proliferation of cancer cells...?
The alternation in normal expression of enzymes is likely to cause a change in the metabolic pool of biochemicals. Lipases do provide more by products on hydrolysis of fats and may promote malignancy. Accumulation of fat bodies - lipoma is an example.
Directly taken from the abstract or the attached paper “Lipases are enzymes that catalyze the hydrolysis of lipids. Based on protein structures and sequences, lipases can be classified into different protein families. The majority of conventional mammalian lipases are members of the protein super-families of serine este- rases and alpha-beta hydrolases. Differential expression of lipases and related alpha-beta hydrolases in tumor cells has been observed. The physiological or patho-physiological functions of these tumor related enzymes are largely unknown. However, lipases are not only involved in energy metabolism but also in the metabolism of bioactive molecules, e.g. phosphatidic acid or arachidonic acid, suggest- ing that tumor-specifically expressed lipases might be interesting targets for the development of future treatment strategies. Moreover, independent of the patho-physiological function, tumor associated lipases can serve as targets for immunological treatment strategies. In addition, lipases with exclusive expression in single tumor entities can serve as potential diagnostic targets.”
Dear Mariella Jacqueline..
Thank you for your msg..
I have read that paper and gave reference also in my PhD papers..
My exact question is..
Can lipase cause cancer ....? Or not...?
http://chemocare.com/chemotherapy/side-effects/hyperlipasemia-high-lipase.aspx
In short yes, apart from other cancers the mean one that goes undetected bids pancreatic cancer.
Myself I have my gallbladder removed and I constantly get my pancreas checked in order to make sure my levels are normal so my lipase levels of my bloodstream are not above average to ensure that I am not susceptible to pancreatic cancer as a gallbladder survivor at the age of 21 having it removed now I am much older at 27, I need to ensure that I do not ovary use/oxidize the pancreas too much. So yes lipase plays a role in cancer with high levels in the blood stream creating and causing tumors/pancreatic cancer that goes often undetected for years
Did That answer your question if not please let me know what I would further assist you happily
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