A genetic disease or disorder is the result of changes, or mutations, in an individual’s DNA. A mutation is a change in the letters (DNA sequence) that make up a gene. This is sometimes referred to as a “spelling” mistake. Genes code for proteins, the molecules that carry out most of the work, perform most life functions, and make up the majority of cellular structures. When a gene is mutated so that its protein product can no longer carry out its normal function, a disorder can result.
Some of these genetic abnormalities can lead to cancer, while others lead to various other health conditions. Genetic disorders may be heritable and passed on from family members or non-heritable and acquired during a person’s lifetime. Acquired genetic disorders refer to conditions caused by acquired mutations or changes in parts of the DNA. These conditions only become heritable if the mutation occurs in the germ line. To what extent a person suffers form a genetic condition may be determined to some degree by environmental factors.
Genetic diseases are those diseases which are caused due to changes in genetic material. Some of the examples of such diseases are Haemophilia, Sickle cell anaemia, Down's syndrome etc.
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Disease is caused by disordering of an ordered state. Likewise genetic disease may be caused by disordering the genetic order.
Genetic disorder can be induced by potential oxidants that include radiation, potentially toxic chemicals like the pesticides; pharmaceuticals like the antibiotics. Oxidants have the capacity to split one or the other gene/allele and thus create genetic disorder. You might find some interesting in my paper: Energetics of Virus Pathogenicity/ Virus-Host Cell Interaction Oxidative Dehydration Theory on Life Processes-Part 4, also available on ResearchGate site at https://www.researchgate.net/publication/310460160_Energetics_of_Virus_Pathogenicity_Virus-Host_Cell_Interaction_Oxidative_Dehydration_Theory_on_Life_Processes-Part_4
If you want case studies you may benefit from my Book, Pesticides, Toxicity, Specificity and Politics, also available on the above site.
Mirza Arshad Ali Beg
Research Energetics of Virus Pathogenicity/ Virus-Host Cell Interacti...
Genetic disease is a disease caused by an abnormality in an individual's genome. Cystic fibrosis, Huntington's disease, Marfan syndrome and sickle cell anaemia are the examples of genetic diseases.
Genetic diseases could be mutation of gene or polymorphisms. The most common diseases are single nucleotide polymorphisms which cause diseases like Chronic periodontitis ( SNP of IL1Alpha and Beta), Agressive Periodontitis, Chediak higashi disease, Down's syndrome.