Hi,
We are doing focused scSeq of lung cancer and we need a panel of genes to identify and differentiate the lung epithelial cells from other cell types of lung. What genes would be useful?
Best regards,
Morten
EPCAM and CDH 1 are Lung epithelium marker for alveolar type cell .
Increased activation of the TRPM8 variant in human lung epithelial cells leads to increased expression of several cytokine and chemokine genes, including IL-1alpha, -1beta, -4, -6, -8, and -13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and TNF-alpha
Sabnis, A. S., Reilly, C. A., Veranth, J. M., & Yost, G. S. (2008). Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures. American journal of physiology. Lung cellular and molecular physiology, 295(1), L194–L200. https://doi.org/10.1152/ajplung.00072.2008
Significantly, gene expression associated with ciliogenesis is evident in bronchial epithelium, and includes the expression of transcripts specifying axonemal proteins DNAI2, SPAG6, ASP, and FOXJ1 transcription factor. Moreover, expression of potential regulators of ciliogenesis such as MDAC1, NYD-SP29, ARMC3, and ARMC4 were also identified.
Lonergan, K. M., Chari, R., Deleeuw, R. J., Shadeo, A., Chi, B., Tsao, M. S., Jones, S., Marra, M., Ling, V., Ng, R., Macaulay, C., Lam, S., & Lam, W. L. (2006). Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. American journal of respiratory cell and molecular biology, 35(6), 651–661. https://doi.org/10.1165/rcmb.2006-0056OC
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