What cell line is best for studying a drug effect on the dengue virus?

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Malcolm Nobre

Hello,

Please refer to the research article given below.

https://doi.org/10.1093/gigascience/gix135

PMID: 29329394

Best.

Franck Touret

Hi,

there is no just one cell line to explore for studying a drug effect. I am afraid you have to test more than one. You can start with the basics: one mamalian (HUH7 of VeroE6) in parrallel with one mosquito (C6/36) and then go to more complex and relevant models.

You can find the evaluation of a drug against Dengue in many cell lines in this article :

https://www.nature.com/articles/s41586-021-03990-6

Good luck

Best

Sudip Kumar Dutta

I use Vero E6 and LLCMK cells, to study antiviral activates of natural compounds against dengue virus.