I have prepared some organic azide molecules. I would like to know is it possible to react these azides with acetonitrile to form tetrazole rings. please give the procedure if anybody knows.
Generally no. The activation energy for a 1,3-dipolar cycloaddition with acetonitrile is too high, thermal decomposition of the azide occurs before the reaction can take place.
Additionally the lewis basicity of nitriles is too low compared to that of the azide to allow for lewis acid catalysis and many transition metals effect decomposition of azides. It has been tried, a lot. It doesn't generally work.
However, you can use activated nitriles to form tetrazoles. Cyanoformates, trichloroacetonitrile, tosyl and acyl cyanides are known to react to form substituted tetrazoles. There may be other examples in the literature.
Conditions to synthesize Tetrazole ring by reacting organic azide and acetonitrile under refluxing condition which is 1,3-dipolar addition of azide to nitrile.