You can combine just about anything with anything else, although clearly not two drugs with the same action like TNF inhibitors. There is not much evidence for specific combinations involving synergies or acting together although methotrexate probably reduces immune reactions to infliximab. So with about a dozen commonly used drugs (not counting analgesics/anti-inflammatories) you probably have 100 binary combinations and yet more tertiary or quaternary combinations. Maybe the question is why would one want to know?

I want to know which all became successful in treating Rheumatoid arthritis

For RA, we use methotrexate plus/or antiTNF agent to treat articulair pain and inflammation, which the most efficient ; moreover, second, third or more line treatment are available, using rituximab, antiIl1, antiIl6, orencia or others biological treatment, without any evidence study yet.

It depends on RA activity and individual therapeutic response...

I'm still not sure why you would want to know, Snijesh. The situation is extremely complex with lots of unknowns and it seems to me it would be very easy to get a distorted view on the basis of such an out of context question.

There is nice guidelines on Rheumatoid Arthritis diagnosis and treatment from the American College of Rheumatology (ACR) and form the European League of Rheumatology (EULAR) and even from national societies such as the Brazilian Society of Rheumatology (society that I am associated).

Focus on the real etiology of the RA., Our Curative Breakthrough Treatment is upcoming for international publication. The good news is that now patient worldwide 

will be saved from the steroidal therapy.

Prof. Dr. Shahid H. Sheikh

Chairman: NIDS Treatment & Research Center/ www.nids.org.pk

Lahore, Pakistan

92300-481-6677