What are normal concentrations of thrombin in human serum? Are these concentrations representative for the normal thrombin concentration in blood?
See this paper:
Müller J, Becher T, Braunstein J, Berdel P, Gravius S, Rohrbach F, Oldenburg J, Mayer G, Pötzsch B. Profiling of active thrombin in human blood by supramolecular complexes. Angew Chem Int Ed Engl. 2011 Jun 27;50(27):6075-8
Hi Alexander,
The precursor of thrombin, which is the prothrombin circulates in the blood at a concentration of 1.4 micromolar concentration. The active enzymatic form, Thrombin, has practically no role in the circulation of a normal healthy individual for if it is there it will surely trigger clot formation. Thrombin concentrations in the serum (if at all in apparently normal individuals who may have some unknown predisposition to thrombosis) may be representative of concentrations in the blood.
The normal amidolytic activity of thrombin in EDTA-Plasma is 5.5+-1.1 mIU/ml (mean value +- 1 SD), that is thrombin complexed with alpha-2-macroglobulin. Upon recalcification normal Plasma generates about 0.1-0.2 IU/ml (proteinolytic) thrombin that generates antithrombin-1 (Fibrin) and thrombin gets enclosed in it. Normal serum might have 10-100 IU/ml thrombin.
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