What are the minimum and maximum Blood insulin concentrations in the following conditions?
1) Fasting and postprandial - Non-diabetic lean subjects
2) Fasting and postprandial - Non-diabetic obese subjects
3) Fasting and postprandial - Subjects with Type 2 Diabetes Mellitus (where Insulin resistance, Hyperinsulinemia, hyperglycemia are dominating features).
There is no set standards on the minimum and maximum insulin levels, every laboratory has its own reference levels which are based upon pre and post prandial glucose levels http://emedicine.medscape.com/article/2089224-overview.
also it depends on the physician to take into account several factors to decide low, normal or high levels of insulin.
http://labtestsonline.org/understanding/analytes/insulin/tab/test/
There are no universal insulin ranges to distinguish individuals in the categories you have mentioned. It depends upon population study being conducted: insulin levels of obese/ diabetes compared with non-diabetic subjects. The main issue is defining what is "hyperinsulinemia" in insulin resistant/obese individuals, who have not developed diabetes yet. In such individuals normal glucose levels are maintained by hyper insulin secretion. Generally by the time diabetes develops, insulin secretion is reduced (due to overload on pancreas) and almost 50% beta-cell mass is lost. So one would EXPECT reduced fasting insulin levels (not hyperinsulinemia but hypo-) in diabetics in comparison to non-diabetics.
My opinion is that you need have laboratory standard for such things (since it depends also not only on ELISA kits you use or the age of your group but also of ethnicity, gender, duration of diabetes |if you are interested in diabetes and its treatment| etc. At the same time, you need to understand what is 'normal' and where is boundaries between 'norm' and 'pathology'
I would agree with the above opinions. There are no "normal" versus "abnormal" insulin levels. The so-called "normal range" is a line drawn in the sand by the specific laboratory. Insulin levels are a waste of time in the individual patient when done commercially, and should be left to large clinical studies where low, normal and high levels can be defined by percentile.
I agree with Larry. I can say that in my hands, using my in house RIA, fasting insulin levels range from less than 5 uU/ml to maybe 25 or so, but that range includes healthy controls and T1D pancreas or islet transplant patients and T2D patients. Under conditions ofglucose potentiated arginine induced insulin secretion, Insulin secretion can be quite high, greater than 300 uU/ml.
@ Elizabeth Oseid
Thank you so much Ma'am. Actually I have also found some existing scientific literature suggesting the same.
Regards
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