Dear Sir,

First of all, the effect of polymer on nanoparticle depends mainly on the nature of polymer and the nano object you are dealing with...we can't analyse precisely without knowing the interaction between them..

But basically the formation of nanoparticle and its stability depends on the rate of aggregation of NP within the system..If the polymer material can effectively disperse the NP by a coating mechanism by acting as a matrix or encapsulating agent, the stability of the system will dramatically increase...this is the basic idea used in nanocomposite research..the effect of polymer can also be increased by adding a surfactant...

Reards 

Dear Sir,

First of all, the effect of polymer on nanoparticle depends mainly on the nature of polymer and the nano object you are dealing with...we can't analyse precisely without knowing the interaction between them..

But basically the formation of nanoparticle and its stability depends on the rate of aggregation of NP within the system..If the polymer material can effectively disperse the NP by a coating mechanism by acting as a matrix or encapsulating agent, the stability of the system will dramatically increase...this is the basic idea used in nanocomposite research..the effect of polymer can also be increased by adding a surfactant...

Reards 

Hi Eduard,

Maybe I'm missing something here but it seems that your question is not clear. What do you mean by formation of nanoparticles? Are you synthesizing the nanoparticles in polymer matrices?

Hello,

I am afraid the original question was not completely clear. 

I am making polymer nanoparticles from PLGA-PEG using acetone as the organic solvent via the nanoprecipitation method. A hydrophobic photosensitizing drug is being encapsulated inside during formation and targeting proteins are conjugated post-formation.

How would using polymers of 20kd/5kd as opposed to 15kd/2kd in the precipitation affect the resulting nanoparticles?

Thanks so much!

EF

Dear Eduard, the molecular weight affects the nano size...  Off course. I don't know your method, but you can try to work with the contact time of the polymer with the organic  solvent to take the nano size that you want. The final size is possible to see by MEV or if is a solution, by viscosity. Best regards Luciana 

Dear Eduard,

perhaps this paper will help:

http://www.eurekaselect.com/138302