Using stealth liposome is one of the best option to target cancer cells but it also destroys host cells because liposomes are not able to differentiate exactly between cancer cells and host cells. Targeting through antibody mediated liposomal drug delivery specific for cancer surface receptors may have some immunological complexions. Is there any other method to avoid immune reaction from host? Or Is there any method to specifically target cancer cells? Any Ideas/Suggestions are welcome...
You can think about Aptamers- can be chemically synthesized and selected against normal cells. Another choice is to use stimuli responsive peptide (pH or GSH sensitive) specific for tumor environment.
You can also select ligand-receptor based approach. e.g. Targeting of galactose, mannose to asialoglycoprotein specifically found in liver.
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