Hello,

I work in cancer immunotherapy particularly in CAR T-cells. I have leukaemia cell lines such as KO-52, ksaumi and THP-1. They express my target antigen at different levels. My CARs are also active, they kill ovarian tumour cell line expressing the same antigen but not leukemia cells. I am wondering what are the possible reasons for tumour cells resisting killing in vitro.

Thanks

Abed

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