My research team is investigating reverse vaccinology to identify candidates for anti-parasite vaccines in cattle. I think the weak link in my team is our deficiency in understanding MHC I and II alleles and interactions in the bovine host. We do not have access to a bovine immunologist. Thus, our in silico predictions are suspect, in my opinion.
Is there a good listing of known MHC I and II alleles that we could plug into our reverse vaccinology prediction pipeline. We currently are using the standard list of human alleles in our Vacceed pipeline and I would like to substitute bovine alleles instead of the human.
Our group is getting a lot of pressure to predict these vaccine candidates, but I fear we are going a bit blind without access to a good bovine immunologist. I can understand and tweak all the other steps of the prediction pipeline, but these MHC alleles are a bit of a mystery.
Dear Felix,
What kind of information are you looking for?
A- A list of known Bovine MHC https://www.ebi.ac.uk/ipd/mhc/group/BoLA (In the web page you can find the contact of an expert in that field)
B- A tool to predict epitopes based on Bovine MHC sequences: http://www.cbs.dtu.dk/services/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759033/
C- A database of Bovine MHC – epitope interactions: Morten Nielsen might help you on this, try to get in contcat with him.
I hope this information might have been useful.
Best regards
Max
I think that the proposal of Dr. Massimiliano Baratelli ,is very adecuate and one of the more complette regarding this type of data from bovine,I have intended to contact one old friend of mine who is specialist in that field,as soon as I contact him I will put into contact with you, Dr, Felix Guerrero
Many times I have fullfiled my needs concerning bovine immunology with this friend ,but I have ti ask him if he wants or can!
Sincerely yours
Gustavo
@Massimiliano Baratelli You are WONDERFUL!! THANK YOU!! I will MOST certainly follow up on those links!
@Gustavo Sierra I thank you too! That is very nice and generous of you.
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