11 November 2014 2 7K Report

I want to synthesis the benzofuran by larock reaction, but it always fails.

In my case, I used an iodine compound, NaHCO3, (Pph3)PdCl2, LiCl, internal alkyne compound and DMF as a solvent at 110oC reaction.

The first time, I used a condenser.

NaHCO3 at this temp production H2O reflux, and the reaction only produces a 3 % yield.

Now, I don't know how to fix this problem. 

Should I change the base or not use a condenser? are there any other kind suggestions that can help me fix this problem? 

I referenced these articles for synthesis.

http://www.pubfacts.com/fulltext_frame.php?PMID=22669348&title=Synthesis%20of%20anti-HIV%20lithospermic%20acid%20by%20two%20diverse%20strategies.

Article Synthesis of anti-HIV lithospermic acid by two diverse strategies

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