Do you think there may be a benefit from convalescent plasma, ie a blood donation with antibodies from someone who has had COVID19 and recovered?
Hello DR J S Nurkovich: Research is being carried out on the 'Convalescent Plasma' approach as a treatment for n COV-19 but the glitch lies in the fact that the plasma extracted , will depend on the blood type! Kind regards--
Yes, it is very promising according to research coming out of China.
https://www.healio.com/hematology-oncology/hematology/news/online/%7B75453a03-ea98-4c57-8b50-7997853beabe%7D/convalescent-plasma-transfusion-shows-promise-for-severely-ill-patients-with-covid-19?utm_source=selligent&utm_medium=email&utm_campaign=hematology%20oncology%20news&m_bt=3969949108867
YES!
Please have a look at the following RG link and PDF attachment.
Article Treatment of 5 Critically Ill Patients with COVID-19 with Co...
Article Convalescent plasma as a potential therapy for COVID-19
Article The convalescent sera option for containing COVID-19
It will reduce the virulence of disease / Viral over load .
"Evidence shows that convalescent plasma from patients who have recovered from viral infections can be used as a treatment without the occurrence of severe adverse events. Therefore, it might be worthwhile to test the safety and efficacy of con valescent plasma transfusion in SARS-CoV-2-infected patients."
DOI: 10.1016/S1473-3099(20)30141-9
https://www.nytimes.com/2020/04/01/health/hydroxychloroquine-coronavirus-malaria.html
Article The convalescent sera option for containing COVID-19
Article Treatment of 5 Critically Ill Patients with COVID-19 with Co...
In this RG open question there are some treatment used in Italian hospitals in the dramatic situation of Lombardia
https://www.researchgate.net/post/The_novel_Coronavirus_in_N_Italy_Lombardia_COVID19_2019nCoV_SARSCoV2_shows_a_fatality_rate_compatible_with_SARS-MERS_Why
Compassionate Use of Remdesivir for Patients with Severe Covid-19.
N Engl J Med. 2020 Apr 10.
DOI: 10.1056/NEJMoa2007016
Also reference to the following studies:
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 Apr 13.
doi:10.1001/jama.2020.6019
NIH clinical trial of hydroxychloroquine, a potential therapy for COVID-19, begins. NIH News. 2020 Apr 9.
We know that SARS reacts to that treatment by changing its tropism more to immune cells but is not able to produce more virus in them. If SARS-cov-2 can be managed by the same method, is possible this could be happening in covid-cases?
Several nations have requested Indian Government to send hydroxychloroquine, a antimalarial drug, for treating COVID 19 cases.
I have not yet read any published paper on the potential use of hydroxychloroquine in the treatment of COVID 19 cases.
Currently, research teams composed of virologists, microbiologists, epidemiologists, etc. are working on the development of effective treatment methods in many laboratories of clinics, universities and medical institutes. At present, the opinion prevails that the development of the SARS-CoV-2 coronavirus pandemic causing Covid-19 disease will be fully mastered and successively reduced and eliminated when a vaccine and / or other effective medical therapies are created, e.g. based on isolated human plasma antibodies. who recovered after Covid-19. In addition, created and improved specific therapeutic therapies include, in addition to the issue of treatment with SARS-CoV-2 Coronavirus infection, also other concomitant diseases that have seriously ill people with Covid-19 disease, such as other respiratory diseases, coronary diseases, hypertension, lungs damaged by smoking, atherosclerosis, oncological and other diseases.
Regards,
Dariusz Prokopowicz
I recently communicate with a couple of institutions in connection with FDA in US for fast drug development for my patent “Flavocillin Antibiotics” who knows maybe if it gets entry to fast clinical trials it can be used to treat patients infected with covid-19 .
some of the treatments are
1) An antiviral drug used to treat Ebola may be an effective medicine for patients with severe COVID-19, very preliminary results from part of a clinical trial suggest . 2)Convalescent Plasma Therapy.
3) Interferon alpha-2b has been used in the treatment of COVID-19
4) Chloroquine and hydroxychloroquine have been approved by the U.S. Food and Drug Administration
The body's immune system has been fighting sickness and disease since the creation of man.
"Nutritional Support for Immunity Against Viruses Including the Coronavirus" can be found here with references.
https://www.clinicaleducation.org/news/nutritional-support-for-immunity-against-viruses-including-the-coronavirus/
DR JASMIN -- COVID-19 has no cure. Man's own immune system(IS) has to fight the Virus . The IS needs to be fortified. No medicinal cure will ever be available, perhaps a vaccine in a year's time. The current patients of COVID-19 are given facial respiration , put on oxygen , injected with Vit C to build up the Immunity Defenses --external medication is a cocktail of Remedesivir, hydrochloroquin and another anti inflammatory drug-- may work or again may not. The method is simply put ' hit & trial'. A shadow remains on those who have recovered --these survivors are prone to a relapse . Finally ,anti bodies extracted from these patients cannot be used as an immune therapy as their number is small and contamination is suspected. These factors are stalling the vaccine acquisition process. Another factor is COVID19 patients who show no symptoms --labeled as being asymptomatic. They are carriers and as they show no symptoms they are the most dangerous. The Uncertainty Scale borders on the Infinite . Therefore, the daily death check to give an idea of the spread. No clue yet. Man has never been as helpless before!!
Article On Facing the SARS-CoV-2 (COVID-19) with Combination of Nano...
People who've recovered from COVID-19 have antibodies to the disease in their blood. Doctors call this convalescent plasma. Researchers hope that convalescent plasma can be given to people with severe COVID-19 to boost their ability to fight the virus.
Please check this article.
Dr BITA JAMSHIDI: With deference I wish to point out that 'The approach you have mentioned above labeled 'convalescent plasma therapy' is a viable proposition per se , but when tested it is found that the donors --ex patients declared recovered may still be vulnerable to a relapse. there is no guarantee that a Recovered patient is immune forever. Finally the anto bodies extracted are not in sufficient number to alter the fate of a COVID-19 patient.
DR JASMIN! the drug Remedesivir , though failing a trial test, has been given the status of an emergent curative medication for COVID-19 patients. Regards--
Dear Dr. have a nice Sunday.
In my RG open question about the dramatic situation of Lombardia (N.Italy)
I propose the test of the natural compounds from Artemisia, according to previous extensive bibliographical reviews about toxic effect in potential biocontrol.
I hope this is useful.
RG open question and Artemisia review references: https://www.researchgate.net/post/The_novel_Coronavirus_in_N_Italy_Lombardia_COVID19_2019nCoV_SARSCoV2_shows_a_fatality_rate_compatible_with_SARS-MERS_Why#view=5eabf2ae32592944281a872b
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https://www.researchgate.net/figure/ResGa-FxFac-post_fig102_339781431
|n.2|....The following 12 virus species have been recognized, both DNA-virus and RNAvirus, both phyto-virus and zoo-virus: BVDV bovine viral diarrhea virus; COPV, canine papilloma virus; DEN/2, dengue virus 1; FIV, feline immunodeficiency virus; HBV, human hepatitis B virus; HCMV, human cito-megalo virus; HFLUV, human influentia virus; HIV, human immunodeficiency virus; HSV/1, human herpes virus 1; HSV/2, human herpes virus 2; JUNV, junin virus; TMV, tobacco mosaic virus. ....
.. ... FROM Artemisia: absinthium, afra, annua, anomala, arborescens, capillaris, caruifolia, douglassiana, herbaalba,verlotorum, vulgaris.....
.. ... Natural compounds: aesculetina, arcapillina, artemisinina, artesunate, beta-arteannuina, beta-sitosterolo, deidro-artemisinina, deossi-artemisinina, isorhamnetina, N-N-N-3p-coumaroil-spermidina, stigmasterolo.
Initially just symptomatic and then according to the severity oxygen, antibiotic even ventilator might be required. Drugs are different in different context. USA and few countries approved the use of REMDESIVIR. Plasma therapy has been introduced too.
Yes, there is a benefit of curing COVID-19 people using convalescent sera through passive immunization- transfer of protective potential antibodies from peoples who have recovered from COVID-19 to a person who is at a high risk of SARS-CoV-2 infection, because, here, risk is less and expected result is greater.
Yes, some countries already use plasma-based therapy for treating a seriously ill with Covid-19, as it has been found that people with this disease have recovered faster and have had a milder progression from the disease. Currently (mid-August 2020), many countries are already using blood plasma from a person who recovered from Covid-19 disease or had a mild SARS-CoV-2 coronavirus infection. In such a person, the blood contains antibodies that destroy the SARS-CoV-2 coronavirus. The person who recovered therefore acquired natural immunity to this type of SARS-CoV-2 Coronavirus.
Best regards,
Dariusz Prokopowicz
Because convalescent plasma for the treatment of COVID-19 has not yet been approved for use by FDA, it is regulated as an investigational product. As such, its administration must be under the EUA or an IND. FDA does not collect convalescent plasma or provide convalescent plasma. Health care providers or acute care facilities should obtain convalescent plasma from an FDA registered or licensed blood establishment. For a closer look :
https://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/recommendations-investigational-covid-19-convalescent-plasma
How can blood from a survivor help a patient with COVID-19:
https://www.sciencemag.org/news/2020/05/can-plasma-covid-19-survivors-help-save-others
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