Trametinib by intraperitoneal injection?

08 March 2017 1 3K Report

Trials of anti-cancer compounds (for instance Erlotinib) in mice usually deliver the compound by intraperitoneal injection (IP). An exception seems to be Trametinib, which in all reports I have seen was delivered orally (with food or by oral gavage). Does anyone have experience with delivering Trametinib by intraperitoneal injection, or know of reports where this was done, or know a reason why this is not done?

Marialuigina Fruscella

Intraperitoneal Tametinib in mouse as in human, represents a rapid absorptiont's view .

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