Can anybody direct me to the best possible papers that have demonstrated that DNA methylation patterns in humans show tissue/lineage specific differences.
Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL,
Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A. Charting a dynamic DNA
methylation landscape of the human genome. Nature. 2013 Aug 22;500(7463):477-81.
doi: 10.1038/nature12433. Epub 2013 Aug 7. PubMed PMID: 23925113; PubMed Central PMCID: PMC3821869.
Zilbauer M, Rayner TF, Clark C, Coffey AJ, Joyce CJ, Palta P, Palotie A, Lyons
PA, Smith KG. Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.
Blood. 2013 Dec 12;122(25):e52-60. doi: 10.1182/blood-2013-05-503201. Epub 2013 Oct 24. PubMed PMID: 24159175; PubMed Central PMCID: PMC3862273.
Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen
A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker
Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific hypomethylation in the regulation of cell identity genes
Liu H1, Liu X2, Zhang S3, Lv J4, Li S3, Shang S3, Jia S3, Wei Y3, Wang F3, Su J3, Wu Q4, Zhang Y5.
PMID: 26635396 [PubMed - in process] PMCID: PMC4705665