At present, the flow resistance detection method is widely used to count the red blood cells（RBC） and platelets（PLT） in clinical practice. (the principle is shown in Figure 1).
The question is, the amplitude of the pulse signal only related to the cell volume?
Is the signal amplitude the same for the same volume but different shape RBC(Fig 2 shows different shape RBC)? Has anyone done relevant experiments, thank you.
It seems the amplitude of the pulse only related to the cell volume, Or we can ignore the difference when RBC and PLT counting.
The Pulse amplitude solely depends on the amount of electrolyte displaced by the particle in the orifice. Shape and volume of the particle is tricky in this case. Particles of different shape but same volume might have small changes in amplitude until and unless the particles do not cover the whole width of the orifice.
I have a question what are you using for constant flow for this setup?
Any syringe pump?
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