Dear researchers,
What is your opinion, is it better to use small or large stem cells for therapeutic use, in theory and practice?
Previous findings indicate that i.v. application of MSCs with a diameter ˃25 um resulted in microinfarctions. Does anyone think that the application of large cells is better, for example, for local application, and small cells for systematic application?
Dear Jasmin
MSCs during culture expanding undergo some morphological changes .Their diameter increse up to 20 micron and in iv adminestration the majoraty of them will be entrapmented in the lungs.But that is no problem for systemic adminestration.
Hello
For the second part of your question I agree with Hamed Ghazavi , while the issue of the best in stem cells significant effort is required for establishing and characterizing stem cell lines ( Small or large ) and comparing behavior and testing potential applications on animal and human for both
Good Luck
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