Since DAMPs recognize a range of molecules, do they need a particular receptor to activate inflammasomes?

14 June 2013 1 278 Report

Damage associated molecular patterns (DAMPs) recognize sterile signals generated by stress by the affected cells. Sterile signals include a range of molecules.

Jordan R. Yaron

A good example of a sterile DAMP is extracellular ATP, which may be released by necrotic or infected cells nearby, or by blunt trauma to an area. ATP is recognized by the P2X7 receptor expressed on cells of the monocyte/macrophage lineage. This leads to potent activation of the NLRP3 inflammasome in primed macrophages. Knockout or knockdown of the P2X7 receptor, the main purinergic receptor for ATP, strongly reduces or abolishes NLRP3 inflammasome assembly.

This is one example of a particular receptor being required to activate an inflammasome.

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