The SARS COV2 Pandemic has caused havoc, economic catastrophes, and death worldwide for one year. According to kff.org, on January 31, 2021, the total worldwide cases are 102,580,465. New cases in 1 day are 511,251. The total number of deaths worldwide is 2,219,911. And the one day total of deaths is 13,465. The United States is by far the leader in all statistical data.
The SARS COV2 has had over 5 genomic shifts of its spike protein. These shifts have become greatly concerning due to increased virulence and death in at least one strain and a decrease in current vaccine efficacy in another.
The spike protein is responsible for gaining access to humans by way of the human Angiotensin-Converting Enzyme 2 (ACE-2). The binding of the spike protein to ACE-2 is a critical focal point for researchers to create vaccines that will cause human antibodies to be created that are specific to the antigenic determinant of the spike protein. This does not mean the entire length or area of the spike protein. Only a small sequence of the protein is the target. The mRNA vaccines are complex and have been under developmental refinement for decades and involve a high number of steps such as the incorporation of human Antigen Presenting Cells (APC), Endosome release of mRNA, transcription, immune activation for antibodies, and the list goes on.
This pandemic has initiated over 200 pharmaceutical companies to attempt vaccine research and production. In my opinion, based on the genomic shift of the SARS COV2 spike protein, there must be a concerted effort to create as many mRNA vaccines as we can to target most if not all of the spike protein structure. Meaning yes we would be giving many injections or even a pot pouri of vaccine such as the annual Influenza vaccines. The difference here is that the many vaccines in the annual influenza injections are for different types and variants of viruses. The concerted effort would be only for the SARS COV2 spike and its new variants. Opinions?
References:
COVID-19 Coronavirus Tracker – Updated as of January 31 | KFF
Liu M. A. (2019). A Comparison of Plasmid DNA and mRNA as Vaccine Technologies. Vaccines, 7(2), 37. https://doi.org/10.3390/vaccines7020037
Wang, Y., Zhang, L., Xu, Z., Miao, L., & Huang, L. (2018). mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma. Molecular therapy : the journal of the American Society of Gene Therapy, 26(2), 420–434. https://doi.org/10.1016/j.ymthe.2017.11.009
n fact, he puts the question wrong. you need to research everything that is possible to research
n fact, he puts the question wrong. you need to research everything that is possible to research
Jaba Tkemaladze This is why you are not the head of the World Health Organisation. Of course, we continue other research for COVID-19.
Let me rephrase... I am specifically speaking of the successful mRNA pharmaceutical companies that the current vaccines are being distributed today for the SARS COV2 spike protein. They are all mRNA and they sofar as I know are only targeting the spike or a part of the spike. I am asking if we should do a large-scale campaign to target the entire spike? This could get in front of the variants. It also could seriously sensitize the immune system.
It is also my opinion that in these particular times we are in, which mostly is in uncharted territories, we need to think outside of the box, and execute new options ideas fast and with precision. Does it to you Jaba Tkemaladze look like we are winning on any front during this world crisis?
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